Journal: Experimental and Therapeutic Medicine
Article Title: Human adipose-derived mesenchymal stem cells repair cisplatin-induced acute kidney injury through antiapoptotic pathways
doi: 10.3892/etm.2015.2505
Figure Lengend Snippet: Kidney functional recovery and structural repair using human AD-MSCs in animals with acute kidney injury (AKI). (A) Renal function was assessed daily by the levels of BUN, serum Ccr, urinary mALB and β2 mG. Data are presented as mean ± standard error of the mean (SEM). *P<0.01 and **P<0.005, cisplatin + saline group vs. cisplatin + AD-MSCs group. (B) Representative images from H&E and PAS staining of the kidney sections from the healthy control, cisplatin + saline and cisplatin + human AD-MSCs groups (magnification, × 200). (C) Histopathological scoring of cisplatin-induced kidney tubular injury, as indicated with tubular necrosis, cast formation, loss of brush border and intratubular debris. Histopathological scoring was based on the percentage of affected tubules in the kidney sections. Data are presented as the mean ± SEM. **P<0.005, between indicated groups. AD-MSCs, adipose-derived mesenchymal stem cells; BUN, blood urea nitrogen; Ccr, creatinine clearance rate; mALB, microalbumin; β2 mG, microglobulin; U, urinary; H&E, hematoxylin and eosin; PAS, periodic acid-Schiff.
Article Snippet: Rats were housed in metabolism cages (Nanjing Bian Zhen Bio-science Company, Nanjing, China), and the blood serum and urine were collected every 24 h for determination of renal function by biochemistry analysis, which included measurements of the serum blood urea nitrogen (BUN) level (48T/96T; Biofine, Blaine, WA, USA), the creatinine clearance rate (Ccr) (48T/96T; Shanghai Yanjin Bio-science Company, Shanghai, China), urinary microalbumin (mALB) (cat. no. {"type":"entrez-protein","attrs":{"text":"ARB12655","term_id":"1168039453","term_text":"ARB12655"}} ARB12655 ; Beijing Ai Ran Bio-tech Ltd., Beijing, China) and β2 microglobulin (β2 mG) (Shanghai Yuanyan Bio-science Limited Company, Shanghai, China).
Techniques: Functional Assay, Saline, Staining, Control, Derivative Assay
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